The Midwest ISO operates and monitors the region’s electric transmission infrastructure, is the sole decision-making authority on the provision of transmission service in in accordance with their FERC-approved tariff, and manages one of the world’s largest energy markets. Significant challenges exist in developing reliability and market mechanisms for their varied stakeholders. Todd Hillman, Executive Director, Market Development and Services, describes the key challenges and opportunities that the Midwest ISO is facing, including their approach to and status of demand response. This background is of interest to companies inside and outside of the region as they think about and formulate their Industrial Energy Strategies.