In The Wall Street Journal, the capabilities of manufacturing in the pharmaceutical industry were claimed to lag significantly behind potato chip makers. After calming one’s nerves, an honest self-assessment would suggest that as an industry we do tend to be risk-averse, and installation of available technology is often hampered by perceived regulatory hurdles (i.e., paperwork). In this talk, we discuss the technology in our pilot plant; in particular, plug-n-play equipment utilizing Bus technologies and at-line Process Analytics, and the Instrument Society of America’s Batch Control Methodology (ISA S88.01). The installed system provides electronic execution of batches, more flexible use of portable equipment, and a data architecture that allows desktop access of process data to enhance the creation of the development history for regulatory filings and technology transition.